You should get a hold of me - I consult for playing card designers.
One thing you should know off the bat - plastic decks are NOT CHEAP, especially when you're talking about a custom design. If you want to price your decks at about $20 a pop, fine, but if you want them at a price point mere mortals consider affordable, you'll be working with paper cards instead. Popular designer Randy Butterfield (who was also a client at the time) created a deck in plastic with glow-in-the-dark elements that was based on another deck he'd just funded on Kickstarter - the single-deck standard price $19 a pack, with an early bird price of $16 and bulk pricing as low as $12.33 standard/$11.50 early bird for a dozen decks. Even playing card collectors would consider these prices as higher than typical, typical being more in the range of $10-$15 depending on the deck's features (artist, rarity, quality, additional features, etc.).
Your design sticks pretty closely to that of a standard pack of cards, so I don't see that there will be issues regarding playability and usability. But you have to accept up front that your deck will be a novelty regardless - and that novelty is not a curse word. Rubik's Cube, the Pet Rock and Tamagotchi were all "novelties" - I'd kill for a fraction of what they earned. The most popular project on Kickstarter to date is a novelty card game called "Exploding Kittens" which earned nearly $9 million. No, you are not likely to make money anywhere in that ballpark, but you should banish the idea from your head that a novelty is a bad thing - it's merchandise for a comic which in itself is a novelty, so the deck will also be a novelty.
Are you planning to use "Kn" for Knight instead of "J" for Jack in the deck? Some old-school (as in "century-old-school") decks used this, but the trend died out of people mixing up Knights for Kings. For the sake of familiarity and ease of use for your buyers, it's better to stick to the International Standard design in terms of suits and values. If you want to really nail that look from your comic, consider making a deck with extra cards that cover any non-standard cards you presented.