I have a Dell Studio and while the components are astounding for the price, the build quality is terrible. I find the same with Toshiba; if you open them up, you can see that they haven't thought through the cooling system. If your GPU overheats, it can cause serious problems. Dell, for example, in my laptop have placed the exhaust for the cooling fan in such a position that the screen completely covers it when it's open. The intake is directly underneath, so anything but a hard, flat, clean surface will give problems.
Honestly, the only laptops I've seen that are done well are Macs but I'm just talking about the build quality; I hate the software so much (you could just put linux on it, then it'd rock).
I would strongly consider whether you really, really need the portability of a laptop for what you want as you could build a desktop computer that was much more powerful for much less money and it won't give you overheating problems.